PDRN – Plinest / Rejuran S

PDRN (Polydeoxyribonucleotide) injectables such as Plinest and Rejuran S are regenerative treatments formulated to repair damaged skin tissue, improve elasticity, and restore smoother skin. Both treatments use highly purified DNA fragments derived from fish sources and have been clinically studied for their ability to stimulate collagen production, support skin healing, and enhance skin texture.While Plinest is widely used across Europe for skin repair and hydration, Rejuran S is developed in South Korea with a thicker consistency to target depressed scars more precisely.

Sessions Required
3 sessions and above
Duration of Results
Gradual improvement seen over weeks
Session Duration
45 mins
Downtime
Minimal downtime
Skin Concerns
Acne scars Stretch marks Surgical or injury-related scars Textural irregularities
Acne scars
Stretch marks
Surgical or injury-related scars
Textural irregularities

About This Treatment

PDRN works at a cellular level to stimulate skin regeneration by activating fibroblasts, enhancing collagen synthesis, and repairing damaged tissue. Both Plinest and Rejuran S are designed to restore skin structure and support long-term skin renewal.

Rejuran S is ideal for sunken or rolling atrophic scars due to its thicker consistency, delivering targeted regeneration into deeper tissue layers. Plinest supports general skin recovery, particularly for sensitive or post-inflammation skin.

Together, these treatments help rebuild the skin’s dermal architecture and improve the appearance of pitted or uneven texture.

How Does It Work?

  • Injected directly into areas of concern to stimulate tissue regeneration

  • Activates fibroblast activity and collagen production

  • Supports dermal healing, structure, and hydration

  • Improves elasticity and overall skin resilience

Key Benefits

  •  Improves Depressed Scars
     Fills in atrophic scars and promotes smoother skin texture

  • Strengthens Skin From Within
    Reinforces weakened skin and boosts elasticity in previously damaged areas

  • Accelerates Skin Repair
    Ideal post-acne or post-laser to support barrier recovery and healing

Frequently Asked Questions

What is PDRN and how is it used in Plinest or Rejuran S?

PDRN (Polydeoxyribonucleotide) is a DNA-derived molecule that stimulates collagen production and cellular repair. In Plinest and Rejuran S, PDRN is injected into the skin to activate regeneration in areas of damage, scarring, or fragility.

Unlike hyaluronic acid skinboosters that mainly hydrate the skin and improve moisture retention, PDRN treatments focus on skin repair and regeneration. They work on a deeper level to enhance skin quality, texture, and resilience over time.

Yes. Plinest and Rejuran S are commonly paired with microneedling, fractional laser, or subcision to enhance outcomes, especially for acne scars.

Avoid makeup and active skincare for 24 hours. Gentle cleansers and moisturisers are recommended. Sun protection is essential during the healing phase.