PDRN stands for Polydeoxyribonucleotide. These are tiny fragments of DNA derived from highly purified marine sources, most commonly salmon or trout. Because the DNA structure of these marine sources is very similar to human DNA, the body recognises and accepts these fragments naturally, using them as building blocks to support its own repair and regeneration process. Examples of PDRN/PN-based skinboosters commonly used in the aesthetic industry include Rejuran, Plinest, and Plenhyage.
Once injected into the skin, polynucleotides work in 2 key ways:
They help the skin repair itself. Polynucleotides are absorbed by the skin cells responsible for producing collagen and elastin. These cells then use the polynucleotides as raw material to regenerate and work more actively. Think of it as giving your skin cells the fuel they need to do their jobs properly again.
They reduce inflammation and support healing. Polynucleotides trigger the release of natural healing signals in the skin that reduce inflammation, support the growth of healthy new tissue, and improve the skin’s ability to recover from damage. This is why these treatments are particularly effective for skin that has been through a lot, whether from acne, laser treatments, or general environmental stress.
Over a course of sessions, the result is skin that becomes structurally stronger, firmer, better hydrated, and more resilient, with improvements that look entirely natural because they come from the skin’s own biology.
At Euphie, we offer a curated range of polynucleotide products including Plinest, Plinest Fast, Rejuran Healer, Rejuran I and Rejuran S Each is selected for its formulation quality and clinical track record, and your doctor will recommend the most appropriate product based on your skin concerns and goals.
Developed in Italy using a high-purity process with trout-derived polynucleotides. Plinest focuses on structural rejuvenation of the skin, stimulating collagen and improving overall skin quality over time. It is suited for patients looking for meaningful, long-term improvement in skin firmness, texture, and radiance.
A lighter, more fluid version of Plinest specifically formulated for the delicate skin around the eye area. It targets fine lines, dark circles, and thinning skin with a consistency gentle enough for this sensitive zone.
A Korean-developed product using salmon-derived polynucleotides. Rejuran Healer is particularly valued for its ability to calm, heal, and repair skin that has been damaged, sensitised, or stressed by previous treatments or environmental factors. It is a go-to for post-laser recovery and skin barrier restoration.
A thicker formulation specifically designed for acne scar treatment. Rejuran S is injected directly into or beneath depressed scars, targeting their depth and texture from below and stimulating collagen regeneration within the scarred tissue.
A lighter formulation designed specifically for the eye area, addressing fine lines, dark circles, and crepey under-eye skin with a consistency safe for injection into this delicate zone.
As we age, the skin cells responsible for producing collagen and elastin naturally slow down. The skin becomes thinner, less bouncy, and takes on a duller, more fatigued appearance. Fine lines settle in, and areas like the eyes, cheeks, and neck begin to develop a crepey quality that reflects the loss of structural density beneath the surface.
Polynucleotide treatments directly stimulate these cells to become more active again, gradually rebuilding skin thickness, firmness, elasticity, and overall radiance. Over a course of sessions, most patients notice their skin looks healthier, more lifted, and more refreshed, with an improvement that reads as naturally better-looking skin rather than an obviously treated appearance.
One of the things Rejuran Healer does particularly well is calm and repair skin that has been through a lot. If your skin has been sensitised by laser treatments, is prone to redness and reactivity, or has been worn down by acne, sun exposure, or environmental stress, Rejuran Healer helps restore the skin’s barrier and its ability to protect and heal itself. Many patients incorporate it into their recovery routine after laser procedures or acne treatment to speed up healing and improve their results.
If your skin feels constantly sensitive, reactive, or prone to flares, it is often a sign that the skin barrier has been compromised. Plinest and Rejuran help by rebuilding the structure of the skin from within, making the barrier progressively stronger and more resilient. Over time, skin that was once easily irritated becomes better at protecting itself and maintaining its own moisture.
When a pimple heals, the inflammation underneath can damage the skin’s collagen structure, leaving behind dips or textured marks. Rejuran S is injected directly into or beneath these depressed scars, delivering a concentrated dose of polynucleotides that acts like a “scaffold” and stimulates collagen regeneration in the scarred tissue. Over several sessions, the scar gradually fills in and the texture of the surrounding skin becomes smoother and more even.
The skin around the eyes is the thinnest on the face and one of the first areas to show signs of ageing, including fine lines, dark circles, and a crepey texture. Plinest Fast and Rejuran I are both formulated with a lighter, more fluid consistency that is safe for injection into this delicate zone. Once delivered, they stimulate collagen production and tissue repair specifically in the eye area, improving skin thickness, reducing fine lines, and brightening the overall appearance of the under-eye skin over a course of sessions.
Managing discomfort is an important part of how our doctors approach Rejuran or Plinest treatment. As the procedure usually involves multiple microinjections across the skin, some areas can feel more sensitive than others depending on type of injectables, the treatment zone and individual tolerance. Patients who have undergone Rejuran before may already be familiar with this sensation.
At Euphie, several steps are taken to make the experience more comfortable. A topical numbing cream is applied before treatment and given adequate time to take effect. Our doctors also tailor their injection technique according to the treatment area and the skin’s condition, adjusting factors such as depth, spacing, and delivery method to reduce unnecessary trauma to the skin. In selected areas, cannulas may also be used to minimise entry points and reduce bruising.
The focus is on ensuring the treatment remains as comfortable and manageable as possible while maintaining precision and effectiveness.
No, they are completely different types of treatments. Fillers add volume and reshape specific features. HA Skinboosters hydrate and nourish through hyaluronic acid. PDRN treatments like Plinest and Rejuran work at a cellular level to help the skin repair its own tissue and produce its own collagen and elastin. The improvement comes from within your skin’s own biology rather than from any added substance.
Both are polynucleotide treatments that work the same way biologically, but they differ in their source and focus. Plinest uses Italian trout-derived polynucleotides and is focused on structural skin rejuvenation and collagen stimulation. Rejuran uses Korean salmon-derived polynucleotides and is particularly valued for its anti-inflammatory and skin-healing properties. Your doctor will recommend the most suitable option for your specific skin condition.
Yes. Polynucleotide treatments have a strong safety record built on decades of use in medical wound healing and tissue repair. The marine-derived DNA is highly purified and very compatible with the human body, meaning it is naturally accepted and used without triggering a negative immune response. Patients with fish or seafood allergies should inform their doctor before treatment.
A standard treatment course is typically 3 to 6 sessions, spaced according to your doctor’s recommendation based on the concern being treated and how your skin responds. Results typically last 4 to 6 months following a completed course. Regular maintenance sessions help sustain the improvements in skin quality, firmness, and radiance over time.
Results are gradual and build naturally over time. Most patients begin to notice improvements in skin texture, hydration, and radiance within 2 to 4 weeks of their first session. More significant improvements in firmness and scar appearance typically become visible over 8 to 12 weeks as collagen production progresses.
Yes. Polynucleotide treatments pair particularly well with laser treatments like Pico Majesty or Sylfirm X, where they support skin repair and recovery after the laser session. They also complement PRP for enhanced regenerative results, and work well alongside skinboosters for patients who want both deep cellular repair and surface hydration. Your doctor will advise the safest and most effective combination for your goals.
These treatments are not recommended for individuals who are pregnant, have an active skin infection in the treatment area, or have a known allergy to polynucleotides or fish-derived products. A thorough consultation with our doctors at Euphie will confirm your suitability before any treatment begins.
